Single Cell Sequencing Techniques and the Impact they have on Medicine and Healthcare

 One such technique for gene sequencing is single cell sequencing, which falls under the category of next-generation sequencing methods. Single cell sequencing looks at the sequence data from individual cells, allowing for a better understanding of cellular differences and the function of a single cell in relation to its microenvironment.

Bioanalytical technology advancements have made it easier to study the dynamic activities of single cells, transcripts, and proteins. It enhances the capacity to research cellular diversity and how it affects both healthy and unwell processes. Bioinformatics is the study and analysis of such vast and intricate biological data, such as genetic codes.

The single cell bioinformatics market is expected to expand significantly thanks to the platforms and technology currently available. The global single cell bioinformatics software and services market was estimated to be worth $205.2 million in 2020, and it is anticipated to grow with a CAGR of 10.89% and reach $634.8 million by 2031, according to a BIS Research market report.

Single Cell Sequencing Techniques' Contribution to Medical Research

Single cell sequencing methods (SCS) are regarded as a potent tool for characterising complex populations and studying rare cells. SCS techniques for DNA and RNA analysis have significantly influenced a wide range of biological disciplines over the past few years, including microbiology, neurobiology, development, tissue mosaicism, immunology, and cancer research. The following section discusses a few of these contributions to SCS technology.

• SSC technology makes it possible to analyse and comprehend various cell types, leading to a better understanding of the genetic variations of cancer. On the basis of DNA/RNA variations, it aids in characterising specific tumours and providing detailed information on the clonal evolution. It may involve researching drug-resistant clones, metastatic clones, cancer stem cells, and lineage analysis.

Additionally, it is employed to learn more in-depth information about intricate neural tissues. Additionally, single-cell sequencing makes it simple to identify cell types and markers. Understanding personal variations in biological processes and developmental biology is aided by this.

• Rare cell type identification and analysis: SSC technology has proven to be very effective in locating and analysing rare cell types. The NGS approach and microarrays are the most frequently used methods for this purpose, but they have some drawbacks.

Single-cell RNA sequencing (scRNASeq) can precisely characterise the hidden population and measure each gene's expression in the case of rare cell types. This aids in getting around the other techniques' cell sample size restriction. A DNA RNA shield can also be used to effectively preserve the samples and improve the results. scRNASeq is the best option for all samples, whether they are plentiful samples of various cell types or rare samples.

• Finding cancer stem cells Everyone is affected differently by a complex disease like cancer in terms of severity, symptoms, and recovery. A significant contributor to tumour growth, drug resistance, and metastasis are cancer stem cells. Analysis of cancer stem cells is crucial early on to ensure accurate cancer diagnosis and treatment based on individual characteristics. In this instance, the SSC analysis is successful.

It aids in the recognition of genetic information, the regulation of genes, and the differentiation of gene expressions in different cells. As a result, it makes it possible for specialists to comprehend intra-tumoral diversity, examine cancer stem cells, and map tumour clones. It offers significant data for cancer research.

Examining developmental trajectories and gene regulatory networks This technology aids in the study of the molecular dynamics of various cell types as they go through various stages of development.

The experts are then able to map the developmental trajectories and comprehend changes in cell fate as a result. Even the transcriptional status of the various individual muscle stem cells and the primary myoblasts can be determined using this technique.

Single-cell sequencing is additionally used to determine the various cellular states and the rate of the cell cycle.

Researchers in science, academia, and the medical field are all beginning to understand the significance of single-cell sequencing techniques. Because of this technology, it is now possible to examine samples at the single-cell level, providing access to in-depth knowledge about disease subtypes and more effective treatments.

SCS has become a significant technology that has significantly advanced healthcare and medicine thanks to its many advantages.

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A Key Tool in Medical Procedure: 4K High-Resolution Imaging Technique

 An essential component of the healthcare sector is imaging methods and equipment. The imaging techniques have advanced significantly since X-rays were first used for diagnosis in 1890. Today, a variety of cutting-edge medical procedures like computed tomography (CT) scans, MRIs, ultrasounds, and nuclear medicine imaging, including positron emission tomography (PET), are frequently used.

These cutting-edge imaging techniques give medical professionals a clear view inside the body and provide detailed information about the body's functions and malfunctions. It has many benefits, including early problem detection, precise diagnosis, ongoing monitoring, and improved medical condition management.

In the healthcare industry, 4K technologies are becoming more and more popular. Since its introduction and subsequent technological advancements, 4K medical imaging has found its best use in operating rooms (OR).

With the advent of 4k resolution technology, the healthcare sector will soon be able to advance imaging methods. With a horizontal resolution of 4000 pixels, or four times that of high definition, 4K technologies are generally referred to as imaging and visualisation technologies (HD).

High-quality imaging techniques are becoming increasingly important as demand for minimally invasive surgery (MIS) increases globally. Patients can clearly benefit from MIS surgery in a number of ways, including reduced blood loss, smaller incisions, shorter hospital stays, and improved procedure accuracy. However, because they rely so heavily on laparoscopic cameras, surgeons currently have restricted vision.

The global 4K medical imaging market is predicted to grow significantly over the coming years as a result of the rising demand for superior visualisation quality in the medical industry and the availability of technologically cutting-edge products for high-definition medical imaging.

According to the BIS Research market report, the global 4K medical imaging market was valued at $822.1 million in 2019 and is anticipated to reach $2.39 billion by 2030, growing at a CAGR of 12.2% during the forecast period 2020-2030.

The benefits of 4K imaging

Less Pixelated Images- Due to the large monitors used in operating rooms, pixelated images are frequently a problem that makes it difficult to distinguish minute details when necessary.

For instance, surgeons will be able to see the pixels in a 31-inch full HD monitor even when viewing it from one metre away. However, pixels cannot be seen in a 4K monitor of the same size when viewed at the same distance. As a result, every last detail will be obvious.

The large pixel sizes of today's HD monitors can be distracting and result in blurry images when viewed up close.

In delicate procedures like operating on tiny blood vessels with tiny sutures, this can be a risky scenario in the operating room. With the aid of 4K monitors, surgeons can see inside patients clearly, resulting in a more effective procedure.

Increased Visibility and Depth Perception- Minimally invasive surgery is currently the preferred technique in many cases because it causes less pain for patients than traditional open surgery. High-resolution imaging technique is one of the advanced technologies that must be incorporated into minimally invasive surgery procedures.

Because clear visibility of the inner organs is critical to the procedure's success, equipment with increased depth perception and picture clarity, including resolution, brightness, and colour, is required.

Clear visibility can be achieved with a 4K monitor and a 4K camera by improving image clarity with the higher pixel density that 4K provides. This increase in clarity has the potential to improve depth perception. By being able to see how light reacts to objects more clearly, surgeons will be able to better sense depth.

Effective Even with Full HD Input- A 4K camera input is recommended to get the most out of a 4K monitor and ensure that images are as crisp and detailed as possible.

However, some models include the smart resolution with sparse coding (SRSC) function, which improves the clarity of expanded images. This works perfectly when displaying full HD images on 4K monitors, allowing the user to fully utilise the 4K monitor without requiring 4K camera input.

Conclusion

Although existing full HD resolution techniques are proving to be extremely useful in their various applications, 4k technology has the potential to improve efficiency even further. Governments and private healthcare stakeholders are making significant investments.

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Gene Cloning is a Molecular Genetics Technique for Creating DNA Copies

 

Gene cloning is an essential component of precision medicine because it ensures that targeted therapies are both safe and effective. It also makes data collection easier for a wide range of therapy dissemination, emphasizing its importance in healthcare.

Gene cloning is a common method or technique used in molecular genetics to duplicate DNA, and its services also aid in drug treatment efficacy monitoring.

The gene cloning service has transformed the distribution of treatments for common diseases. Rapid service development and simultaneous adoption by major corporations have elevated the global gene cloning services market to one of the most profitable markets.

So, what do Gene Cloning Services provide?

A few examples of gene cloning services are:

Gene Expression is the process by which all living cells, including prokaryotes and eukaryotes, function.

Several methods exist for studying and quantifying gene expression and regulation. Some of these approaches are centuries old and well-established, while others, such as multiplex techniques, are relatively new.

Genome Organization: The term "genome organisation" refers to the sequence of the genome rather than its structure. The DNA of an organism is made up of an array of four nucleotides arranged in a specific pattern that provides inherent information. Every creature's genome contains multiple DNA molecules.

Transgenic organisms: These have had their genomes modified. The vast majority of transgenic organisms are created in labs for research.

It is a genetically altered creature whose genetic makeup has been altered using genetic modification techniques, the insertion of altered genes, or the introduction of genes from other organisms. It is the method used the most frequently to acquire genetically modified (GMO) foods.

Gene therapy is a type of treatment that, in addition to treating a hereditary condition, entails inserting one or more genes created in a lab into the genetic material of a patient's cells. To treat and prevent disease, it makes use of genes.

Production of Recombinant Proteins: The biological sciences, biotechnology, and medicine all heavily rely on the production of recombinant proteins. Either cell-based technologies or cell-free technologies can be used to accomplish it. The oldest method of producing a lot of protein is through cell-based systems.

Instead, host cells are chosen based on the gene involved. Different host cells, such as those derived from bacteria, yeast, baculovirus/insect, and mammalian cells, can produce proteins.

According to BIS Research, the global gene cloning services market was valued at $1.98 billion in 2020 and is expected to grow at a CAGR of 17.29% from 2021 to 2031.

Technological Development in Cloning Services

A rise in molecular cloning, molecular diagnostics research, and disease profiling is being driven by improvements in gene cloning services. Additionally, it is anticipated that ongoing technological developments in the services will accelerate market growth.

Research on vector cloning or plasmid at various levels is being done by numerous research institutions, pharmaceutical companies, and laboratories to treat various diseases.

Cloning and subcloning have long been used by molecular and cellular scientists as standard tools.

A crucial step in creating a reliable mammalian cell culture manufacturing platform is efficient clone selection.

These developments offer exceptional opportunities that advance the field of gene cloning services and fuel further expansion of the world market for these services.

The biological validity of the cloned product is now a crucial consideration in the development of cloning techniques. Advances in cancer, cell, and molecular biology in particular have transformed gene therapy.

In short, the goal of gene cloning services is to duplicate DNA. Additionally, it provides prognostic evaluations for a variety of diseases and aid in selecting treatments and keeping track of drug treatment effectiveness.

CAN EMOTIONAL AI HELP BUSINESSES GROW?

People have begun to rely on technology more than ever before as a result of the widespread use of laptops, tablets, and other similar devices in daily life.

Human-technology interaction is constantly evolving and getting more complicated. The world is constantly moving toward a future where artificial intelligence will play a larger role.

Robotic technology that has emotions is capable of handling complex tasks much more effectively. What options does business-related emotional AI technology offer, and how do these robots come to understand emotions?

For a deeper understanding of emotional AI, let's explore the answers to these questions.

Human-to-Machine Communication Using Emotional AI

Through digital media, communication is constantly filtered in the modern world. People send messages or set up video calls instead of having in-person conversations.

Similar to this, people connect to chatbots when they encounter numerous difficulties while browsing through various online stores. It's not always possible to obtain the needed information using these options. Frustrations arise from improper communication and incorrect interpretation of questions.

What if the same technology that makes communication difficult could recognise and respond to user emotion?

The ability of machines to read emotions by analysing various data, such as gestures, facial expressions, voice tones, and the force of keystrokes for determining the human emotional state and appropriately reacting to it, is known as emotional intelligence.

The development of AI may make it possible for machines and people to communicate more naturally, as they do in real-world interactions.

How Can AI Recognize Emotions?

Affective computing, another name for emotional AI, is the use of artificial intelligence to identify various emotions. Such emotional intelligent machines are able to comprehend not only the mind but also various studies on various emotional channels of human communication.

Cameras, sensors, computer vision, speech recognition, deep learning algorithms, and real-world data are all used in the development of emotional AI. The required data is gathered, processed, and compared with other data points by the AI system in order to identify emotions like fear and joy.

As soon as an emotion is detected, the computer analyses it and considers its implications in various contexts. The systems work much better and can more easily identify human emotions when communicating as the emotional database grows.

The demand for the artificial intelligence market has been steadily increasing due to the enormous advantages of emotional AI, with a focus on enhancing the customer experience and fostering better relationships.

The Importance of Emotion AI for Business Growth

Human behaviour is greatly influenced by emotions. From a marketing perspective, the consumer
journey illustrates it. Customers are more likely to be devoted customers under all circumstances when they have positive emotional connections with a brand.

Therefore, brands need a system like emotional AI if they want to improve the customer experience. This system can be useful in the following ways:

• Business leaders can better understand and empathise with customers when they are in need thanks to emotional AI. In order to obtain sufficient customer engagement, it aids businesses in recommending the right services and products to the right customers at the right time.

• AI aids in the generation of targeted results for the variety of customers attempting to interact with a given company. Additionally, emotion AI aids in creating long-term consumer and business relationships based on strong loyalty. By delivering better customer experiences, it enables businesses to keep their current customers and draw in new potential customers.

• The emotion-related feature of facial expression Through cameras, AI enables businesses to better understand the behaviours of their customers. With real-time data, it can analyse the customers' facial expressions to ascertain their current emotional states. Before informing customers about the new services and products, the company can determine where they are anxious, content, and expanding.

Potential Use Cases for Emotion AI

Advertising is the primary application of emotion AI, but there are a number of additional ways that businesses can gain from it, including:

• Intelligent chatbots can aid in bettering customer relationships with a business by identifying different customer types, their motivations, and behaviour.

• Retailers can improve their operations by real-time recording customer responses to prices, products, and other factors using smart CCTV.

• Brands can use emotional AI to test consumer reactions to specific content and make necessary adjustments with the help of cameras coupled with smartphones, televisions, or computers.

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Conclusion

Recent developments in artificial intelligence hold out hope for positive outcomes and applications that can improve customer understanding for businesses. Emotional AI has the potential to improve in accuracy over the next few years, which will help the business expand.

Technological Advancements Leads to Robust Growth in Transcriptomics Market

 

The global transcriptomics market is expected to witness robust growth owing to an increasing number of global companies attempting to tap into the vast potential of this market. With an increasing number of companies attempting to establish synergies in order to enter the market and an increasing number of products acquiring approvals from regulatory bodies, this market will witness tremendous dynamicity.

In 2020, the global transcriptomics market for drug discovery and development was valued at $1.35 billion, which is expected to reach $10.28 million by 2031, growing at the CAGR of 20.22% during the forecast period, 2021-2031.

Growth in this market is driven by increasing awareness toward the application of NGS and RNA-sequencing in transcriptomic research, increase in adoption of personalized medicine, and continuous advancement in the products for transcriptomics research. In addition, an overall rising disposable income in the region is also leading to higher adoption of novel healthcare technologies, thereby bolstering the market for genetic testing. On the other hand, high cost and maintenance of next-generation sequencing and RNA-sequencing platforms and lack of tools for computational analysis are expected to limit market growth in the coming years. 

However, significant challenges restraining the market growth include high cost and maintenance of next-generation sequencing and RNA sequencing platforms and lack of tools for computational analysis. Transcriptomics approach has been able to decipher the mechanism of complex bulk tissue, giving us a deep understanding of heterogeneous cell populations. With the co-analysis of molecules, such as RNA, and protein, at the single-cell level, the researchers can unearth the regulation mechanism associated with RNA transcription and protein translation.

Several companies, including global leaders such as Illumina Inc and QIAGEN, and various regional companies such as Akoya Biosciences, Inc., and Dolomite Bio, are focusing on the development of RNA-sequencing analysis to enable better diagnosis and monitoring of diseases. 

Fastest-Growing Region in the Global Transcriptomics Market

 In conjunction with the ongoing efforts in the U.S. and Europe, the study of genomics and its sequencing application within the pharmaceutical sector has become an increasingly active and global initiative in Asia-Pacific.

With a large geographic area and substantial ethnic, cultural, and genetic diversity, the region has become a focus area for a growing number of genomic and sequencing studies, which is significantly increasing the adoption of robust software solutions for data analysis to derive clinical and research insights. In addition, there have been significant concerns regarding the under-representation of Asia-Pacific (APAC) populations in the global transcriptomics market, further attracting global focus upon the region.

Key Competitors in the Global Transcriptomics Market

For the years 2019 and 2020, the market share of the global transcriptomics market was calculated on the basis of the views of industry experts, product portfolios, and competitive strategies followed by manufacturers. The market dominance was attributed to the company’s role of RNA sequencing in manufacturing. Moreover, the company’s offerings specifically cater to academic and research institutions, which further bolstered its dominance in the market.

The companies clubbed under the “other companies” category primarily include the emerging companies that have mushroomed in the industry. These companies have come into the forefront owing to massive investments from capital ventures and legacy companies in the healthcare industry due to their unique positioning in the market. Companies such as Acea Biosciences Inc RareCyte, Inc. Dolomite Bio., and Menarini Silicon Biosystems have all been instrumental in propelling the growth of the global transcriptomics market.

Key Growth Strategies in the Global Transcriptomics Market

Product launch activities in the market have witnessed an overall growth trend, largely attributable to increased interest in all regions. The market witnessed approximately 96 significant key developments between January 2018 and August 2021.The number of merger and acquisition activities also grew steadily during January 2018-August 2021. 

This growth is attributed to large players acquiring mid-sized players with dedicated manufacturers to provide next-generation sequencing.

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ABOUT BIS HEALTHCARE

 BIS healthcare vertical offers intelligence in the healthcare technology market for precision medicine, robotics and imaging, life sciences and biopharma, medical devices, digital health, and other emerging healthcare technologies, covering the entire industry spectrum. In the past eight years, BIS Healthcare has published more than 50 reports under the precision medicine banner. Additionally, BIS Research has been nominating ‘Top 25 Voices’ in precision medicine on its InsightMonk platform for the past two years successfully.

Rising Cancer Prevalence Leads to Significant Growth in the Liquid Biopsy Market

 One of the most important steps in treating or containing the disease is a timely and accurate diagnosis. The best chance of curing a disease is an early diagnosis, particularly in cases of cancer. The more advanced the cancer stage, the more painful the treatment will be, and the less likely the patient will survive. An early cancer diagnosis is essential for controlling the disease's progression and developing a successful treatment plan.

Cancer symptoms like fatigue, excruciating pain, swollen bumps, etc. typically show up in the later stages of the disease, when it has reached a dangerous stage. Therefore, doctors frequently advise routine cancer screenings, even for people who appear to be in good health.

Diagnosis is a distinct process from screening. It is used to hypothetically identify an undiagnosed disease in a population that appears healthy and asymptomatic using tests, examinations, or other techniques that are simple to use on the target population. A screening procedure includes the entire process, from inviting the target population to ensuring that those who are diagnosed with the disease can access effective treatment.

People are more susceptible to chronic diseases like cancer today because of the toxic environment and poor lifestyle choices. Therefore, the most effective defence against cancer is early diagnosis, prevention, and precaution.

The healthcare sector has benefited greatly from technological development. It has prompted the creation of more effective instruments and methods, significantly raising cancer patients' survival rates as a result.

Liquid biopsy is a non-invasive medical procedure that holds the ability to detect the presence of molecular cancer biomarkers in biological fluids. In this procedure, any non-tissue specimen, particularly body fluids such as blood, urine, stool, saliva, pleural fluid, and cerebral spinal fluid, is used to assess for tumors in the body. Several analytes, such as circulating tumor cells (CTCs), proteins, and circulating tumor DNAs (ctDNA), in the fluid are used to detect the tumor cell.

This procedure can eliminate the need for more expensive, invasive, and painful tumor tissue biopsies to enable dynamic tumor monitoring. Blood is the most common fluid used in liquid biopsy procedures for various types of cancers, while in the case of bladder tumors, urine is the best liquid biopsy component. Urine divided into two compartments can be useful for biomarker detection: supernatant and pellet. Supernatant biomarker consists of partially fragmented cell-free tumor nucleic acids and some other tumor-derived materials, while the pellet primarily consists of exfoliated normal and cancer cells, as well as immune cells, debris, and possible bacteria.

The liquid biopsy technique also plays a critical role in the precision medicine approach, as it confirms the safe and effective application of targeted therapeutics. It helps physicians to analyze tumor-related information through a simple blood test. Liquid biopsy can be used as a better alternative for treatment and recurrence monitoring as it overcomes invasive biopsy challenges of taking a tumor sample again and again during the treatment.

Owing to the increasing burden of cancer cases and increasing adoption of advanced technologies such as next-generation sequencing (NGS) and personalized medicine is leading to significant growth in the liquid biopsy market.

According to the BIS Research report, the global liquid biopsy market is projected to reach $19,066 million by 2032 from $2.58 billion in 2021 at a CAGR of 19.83% during the forecast period 2022-2032.

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To combat the growing health crisis and cancer burden, self-awareness and preemptive checkups are crucial. Thankfully, a number of technological developments are proving to be very helpful in managing such chronic diseases. Future developments in diagnostic and therapeutic techniques are anticipated to revolutionize the healthcare industry.

Are you curious to learn more about the developing technologies in your industry's niche? Obtain the most recent market research and analysis from BIS Research. To learn more, get in touch with us at hello@bisresearch.com

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ABOUT BIS HEALTHCARE

 BIS healthcare vertical offers intelligence in the healthcare technology market for precision medicine, robotics and imaging, life sciences and biopharma, medical devices, digital health, and other emerging healthcare technologies, covering the entire industry spectrum. In the past eight years, BIS Healthcare has published more than 50 reports under the precision medicine banner. Additionally, BIS Research has been nominating ‘Top 25 Voices’ in precision medicine on its InsightMonk platform for the past two years successfully.